Jonathan Savitz, Ph.D.
Title/Position: Assistant Professor, Lab Director
B.S. in Genetics and Psychology (University of the Witwatersrand)
M.S. in Neuropsychology (University of the Witwatersrand)
Ph.D. in Human Genetics (University of Cape Town)
Postdoctoral Fellowship (National Institute of Mental Health)
- Autoimmunity in mood disorders and psychosis
- The effect of inflammation on brain structure and function
- The effect of psychological stress and genetic variants on immune function
- Identifying biomarkers for mood disorders by examining whole genome expression of peripheral blood immune cells
- Imaging genetics
- The impact of nicotine on inflammation in the context of depression
- Immune-modulating compounds as novel treatments for depression
Savitz, J.B., Rauch, S. L., Drevets, W.C. (2013). Clinical Application of Brain Imaging for the Diagnosis of Mood Disorders: The current state of play. Molecular Psychiatry. In press.
Savitz, J., Frank, M.B, Victor, T, Bebak, M, Marino, J.H, Bellgowan, P.S, McKinney, B.A, Bodurka, J, Teague, T.K., Drevets, W.C. (2013). Inflammation and neurological disease-related genes are differentially expressed in depressed patients with mood disorders and correlate with morphometric and functional imaging abnormalities. Brain, Behavior and Immunity. In press.
Savitz, J., Hodgkinson, C.A., Martin-Soelch, C., Shen, P.H., Szczepanik, J., Nugent, A., Herscovitch, P., Grace, A.A., Goldman, D., Drevets, W.C. (2013). The functional DRD3 Ser9Gly polymorphism (rs6280) is pleiotropic, affecting reward as well as movement. PLoS ONE. 8, e54108. [4.1].
Savitz, J., Nugent, A.C., Cannon, D.M., Carlson, P.J., Davis, R., Rallis-Frutos, D., Fromm, S., Herscovitch, P., Drevets, W.C. (2012). Effect of arterial cannulation stress on regional cerebral blood flow in major depressive disorder. Scientific Reports. 2, 308.
Savitz, J.B., Nugent, A.C., Bogers, W., Roiser, J.P., Bain, E.E., Neumeister, A., Zarate, Jr., C.A., Manji, H.K., Cannon, D.M., Marrett, S., Henn, F., Charney, D.S., Drevets, W.C. (2011). Habenula Volume in Bipolar Disorder and Major Depressive Disorder: A High Resolution MRI Study. Biological Psychiatry. 69, 336-343.
Savitz, J., Nugent, A.C., Bogers, W., Liu, L., Sills, R., Luckenbaugh, D., Bain, E.E., Price, J.L., Zarate, C., Manji, H.K., Cannon, D.M., Marrett, S., Charney, D., Drevets, W.C. (2010). Amygdala Volume in Depressed Patients with Bipolar Disorder Assessed using High Resolution 3T MRI: The Impact of Medication. NeuroImage. 49, 2966-2976.
Savitz, J., van der Merwe, L., Stein D.J., Solms, M., Ramesar, R. (2009). Neuropsychological Status of Bipolar Disorder Type I: The Impact of Psychosis. British Journal of Psychiatry. 194, 243-251.
Savitz, J., van der Merwe, L., Stein, D.J., Solms, M., Ramesar, R. (2007). Genotype and childhood sexual trauma moderate neurocognitive performance: A possible role for BDNF and ApoE variants. Biological Psychiatry. 62, 391-399.
Savitz, J. van der Merwe, L., Stein, D.J., Solms, M., Ramesar, R. (2008). Neuropsychological Task Performance in Bipolar Spectrum Illness: Genetics, Medication, Alcohol Abuse and Childhood Trauma. Bipolar Disorders. 10, 479-494.
Savitz, J., van der Merwe, L., Newman, T.K., Solms, M., Stein, D.J., Ramesar, R. (2007). The Relationship Between Childhood Abuse and Dissociation. Is it influenced by catechol-o methyltransferase (COMT) activity? International Journal of Neuropsychopharmacology. 11, 149-161.
Savitz, J.B., Cupido, C.L., Ramesar, R.S. (2006). Trends in Suicidology: Personality as an Endophenotype for Molecular Genetic Investigations. PLoS Medicine. 3, e107.